Many ethical issues associated with the use of stem cells apply to biomedical research generally. Some issues which were discussed above, such as priorities of research and allocation of limited resources, disclosure of truth about benefits and harms, and obtaining consent, are prominent in stem cell research. Paying appropriate attention to research integrity and related matters such as responsible conduct of research, ownership of data, and authorship, are particularly emphasized in this field.
Another relevant general ethical issue is that of conflict of interests. There are financial
interests for researchers who work in this field. Honesty and openness of researchers, along with appropriate independent review of research, are required.
Some issues are more specific and require special attention. For instance, stem cells can be used for the study of normal development of human embryos and for genetic research. Therefore, concerns about germ lines interventions attempting eugenics have been raised (Balint, 2001).
An issue is the principle of subsidiarity, according to which stem cell research can be ethically permissible only if there are no alternatives (DeWert & Mummery, 2003). Some options have been discussed as alternatives of human embryonic stem cells, which consist of: human embryonic germ (hEG) cells, adult stem cells, and xenotransplantation. For comparison of these alternatives, many elements should be analysed, including: burdens and/or risks, the chance of success and applicability, and the time-scale in which clinically useful applications are to be expected (DeWert & Mummery, 2003). Low success rates of the use of hEG cells and uncertain outcomes, and cross-species infections caused by xenotransplantation and high rates of immunity rejection are the barriers for the first and third alternatives.
Adult stem cells experiments have had great success in recent decades. Scientists have been studying them since the 1960s (United Nations Educational, Scientific and Cultural Organization, 2004). Avoidance of immunity system rejection problems is an important advantage of these cells. However, there are many doubts about their developmental potential and their proliferation capacity as a substitute for embryonic stem cells (Kuehnle & Goodell, 2002; Gavaghan, 2001).
As mentioned above, iPS cells are suggested as another alternative for human embryonic stem cells (Hyne, 2008; Takahashi et al., 2007; Blow, 2008). Many experiments have been
done in recent years to test the efficacy and safety of this novel option (Lewis, 2009).
Aborted foetuses are suggested as sources for obtaining germ line stem cells, though critical
issues are raised (Balint, 2001). Women coercion, their safety, stem cell recipient safety, informed consent issues, and vulnerability of the foetus are concerns which cause this suggestion to remain controversial.
According to some advocates, stem cell research can save many lives. But the principle of proportionality urges ethicists to weigh potential benefits and harms. Pursuance of medical progress at any cost does not seem ethical.
Monday, 15 July 2013
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